In a large mixing bowl, whisk together the flour, sugar, baking powder, baking soda, and salt.
In another bowl, whisk together the buttermilk, eggs, melted butter, and vanilla extract.
Pour the wet ingredients into the dry ingredients and stir until just combined. Do not overmix.
Heat a griddle or frying pan over medium heat and lightly grease it. Pour 1/4 cup of batter for each pancake onto the griddle.
Cook until bubbles form on the surface of the pancakes and the edges look set, about 2-3 minutes. Flip and cook for another 1-2 minutes until golden brown.
Serve warm with your favorite toppings.
Notes:
For extra fluffy pancakes, let the batter rest for 10 minutes before cooking.