In a mixing bowl, combine the shrimp, artichoke hearts, mayonnaise, Parmesan cheese, garlic powder, and onion powder. Season with salt and pepper to taste.
Transfer the mixture to a baking dish and spread it out evenly.
Bake in the preheated oven for 25-30 minutes, or until the top is golden and bubbly.
Remove from the oven and let it cool slightly before serving.
Notes:
This casserole is perfect for a family dinner or a potluck. Serve with a side salad or some crusty bread.